Epigalocatequina (EGCG)

foto: The Matcha House

El 27 de marzo 2020, el Dr. M Faheem Khan, un investigador de la ERA Medical University en India, publicó un artículo muy interesante.

"Con respecto al nuevo coronavirus, de las 18 moléculas de alimentos, la sustancia galato de epigalocatequina tenía la mayor actividad antiviral", dijo.

https://www.researchsquare.com/article/rs-19560/v1

Recently, a new and fatal strain of coronavirus named as SARS-CoV-2 (Disease: COVID-19) appeared in Wuhan, China in December of 2019. Due to its fast growing human to human transmission and confirmed cases in nearly every country, it has been declared as pandemic by World Health Organisation (WHO) on 11 March 2020. Till now, there is no therapy such as vaccines and specific therapeutic agents available globally. Inspite of this, some protease inhibitors and antiviral agents namely lopinavir, ritonavir, remdisivir and chloroquine are under investigation and also implemented in several countries as therapeutic agents for the treatment of COVID-19. Seeing the health crisis across the world, it was our aim to find out a suitable drug candidate which could target SARS-CoV-2. For this purpose, molecular docking of 7 proteinsof SARS-CoV-2 was done with 18active constituents that have previously been reported to be antiviral or anti-SARS-CoV agents. The docking results of these 18 compounds were compared with 2 FDA approved drugs that have are currently being used in COVID 19, namely Remdesivir and Chloroquine. Our result revealed that among all, epigallocatechin gallate (EGCG), a major constituent of green tea, is the lead compound that could fit well into the binding sites of docked proteins of SARS-CoV-2. EGCG showed very strong molecular interactions with binding energies -9.30, -8.66, -8.38, -7.57, -7.26, -6.99 and -4.90 kcal/mole for6y2e, 6vw1, 6vww, 6lxt,6vsb, 6lu7 and 6lvnproteins of SARS-CoV-2, respectively.Therefore, EGCG as per our results, should be explored as a drug candidate for the treatment of COVID-19.

A continuación se presentan cinco de los ingredientes activos más efectivos.

1. Galato de epigalocatequina (EGCG, té verde)

2. Curcumina (cúrcuma)

3. Apigenina (perejil, apio, guayaba)

4. Beta glucano (hongos)

5. Miricetina (nueces, uvas, bayas)


Las catequinas se encuentran no solo en el té verde sino también en el té negro y el té oolong hecho de las mismas hojas. Este EGCG solo se encuentra actualmente solo en el té verde. Se requiere un calentamiento de 80ºC para extraer EGCG.


El valor de EGCG de nuestro nuevo Matcha orgánico PRACTICE MATCHA ECO es como lo siguiente:

PRACTICE MATCHA ECO(100g):　6.52g EGCG

PRACTICE MATCHA ECO 30G estará disponible a partir de mayo 2020 en la tienda online de The Matcha House Europe y en las tiendas de Club de Gourmet de El Corte Inglés. 

foto: The Matcha House 

Fuentes:
https://www.researchsquare.com/article/rs-19560/v1

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